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전임교수

교수정보의 상세 화면
장선영
이름
장선영
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연구실 :
약학관316호

연구실번호 :
3454

이메일 :
sychang@ajou.ac.kr

연구관심분야 :
점막 면역학 및 감염 대응기전

홈페이지 :
학력
졸업연도/학교/학위
2004.02 서울대학교대학원 박사
경력 Mar. 1994- Feb. 1998         B.Sc.                   College of Pharmacy, Seoul National University
Mar. 1998- Feb. 2000         M.S.                    College of Pharmacy, Seoul National University    
Mar. 2000- Feb. 2004         Ph.D.            College of Pharmacy, Seoul National University     
 Mar. 2004- Jun. 2004    Post-doctoral fellow        Seoul National University
Jul. 2004- Nov. 2008    Post-doctoral fellow        International Vaccine Institute
Dec. 2008- Sep. 2009    Post-doctoral fellow        Brigham and Women’s Hospital/Harvard Medical School
Oct. 2009-Aug. 2010    Post-doctoral fellow        Massachusetts General Hospital/Harvard Medical School
Sep. 2010-Feb. 2012     Research Scientist       International Vaccine Institute
Mar. 2012-Present          Assistant professor      College of Pharmacy, Ajou University
연구분야 General interests: “Mucosal Immunology and Host Defense”
We are interested in the immune regulation mechanism observed in the mucosal tissues which is called mucosal immunology. Mucosal tissues including gastrointestinal tract, respiratory tract and urogenital tract were exposed to external environment, colonized commensal microbes and serve as an infection route of pathogen. These tissues have established complex and elegant immune system to regulate immunity via immune tolerance to commensal microbes versus to induce strong protective immunity against invading pathogen. Therefore, mucosal immune system is distinct with sterile systemic immune system and developed their unique system. To reveal the puzzling immunological network in these tissues, we are focused on the study for the function of antigen presenting cell group, especially dendritic cells (DCs). In addition, we also have interests about the cross-talk between sterile systemic and mucosal system under disease condition, dendritic cell conditioning under specialized microenvironments, interaction between commensal microbes and immune system and infectious disease including development of vaccines. 

1.    Immune Regulation via Mucosal Dendritic Cells
•    Immune tolerance to oral or circular antigen via intestinal DCs
•    Shaping of adaptive immune responses via mucosal DCs
•    Direct induction mechanism of immunoglobulin class-switching by DCs 
•    Function of C-type lectin receptors on DC
2.    Cross-talk between mucosal immune system and microbes
• Immune tolerance mechanism by commensal microbes
• Immune shaping by commensal microbes
• Correlation between dysbiosis and diseases
• Host Defense to Microbial Infection and Vaccines
3.    Therapeutic Strategy to Immunologic Disorder
• Underlying mechanism and therapeutic strategy to inflammatory bowel disease
• Underlying mechanism and therapeutic strategy to food allergy
• Vaccine development to infectious disease and adjuvant
논문 및 연구활동
연구활동(주요논문)
  • [논문] Autophagy Controls an Intrinsic Host Defense to Bacteria by Promoting Epithelial Cell Survival: A Murine Model (PLoS ONE) - 2013.11
    권미나, 이세나, 양진영, 김동욱, 고현정, Ogawa M, Sasakawa C, 장선영, 윤주헌
  • [논문] Potential therapeutic anti-tumor effect of a Salmonella-based vaccine (HUMAN VACCINES & IMMUNOTHERAPEUTICS) - 2013.08
    고현정, 장선영, 김연정
  • [논문] Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cells (INTERNATIONAL JOURNAL OF CANCER) - 2013.06
    고현정, 홍은혜, 이보라, 이정미, 강창율, 권미나, 장선영, 김윤선
  • [논문] Intratumoral injection of attenuated Salmonella vaccine can induce tumor microenvironmental shift from immune suppressive to immunogenic (VACCINE) - 2013.02
    고현정, 홍은혜, 편아림, 이보라, 권미나, 장선영, 김지원
  • [논문] Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. (IMMUNITY) - 2013.01
    Reinecker HC, Guleng B, Cotoner CA, Arihiro S, Zhao Y, Chiang HS, O'Keeffe M, Liao G, Karp CL, Kweon MN, Sharpe AH, Bhan A, Terhorst C, 장선영, 송주혜
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