교수진/연구실- 교수진
- 전임교수
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| 경력 | 2007~2009 Assistant professor, Clinical Research Institute, Seoul National University Hospital 2009.09~2014.09 Adjunctive professor, Graduate School of Convergence Science and Technology, Seoul National University 2009~2014.08 Associate professor, Department of Biomedical Science, College of Life Science, CHA University 2014.09~present Associate professor, Dept.of Pharmacy, College of Pharmacy, AJOU University |
| 연구분야 | Function Hunting of Med28 Med28 was recently identified as a mediator of transcription complex, which involved in tumorigenesis including breast cancer, prostate cancer. However, its molecular mechanism is not understood. So we isolated binding candidates of med28, and are trying to unveil the molecular mechanism. Many candiates are shown to be associated with cancer progression such as DNA repair, chromosome segregation, suppressor of tumor suppressor, cell-cell signaling. Thus we are studying about the novel regulatory mechanism in cancer onset and progression. p43/AIMP1 and Stem Cell p43/AIMP1 has been known as a multi-functional protein, which take part in immune cell activation, angiogenesis, blood glucose regulation, and wound healing as a cytokine. In addition, p43/AIMP1 regulates TGFb signaling and autoimmune disease in cytoplasm. Interestingly, whole body knock-out of p43/AIMP1 in mouse shows multiple phenotypes including defect of uterus development, petite, ataxia and so on... Thus we generated conditional knock-out mouse to remove p43/AIMP1 tissue specifically. In addition, we are investigating whether the p43/AIMP1 could regulate stem cell mobilization from bone marrow, self-renewal, and differentiation of bone marrow-derived mesenchynal stem cell or hematopoietic stem cell. Furthermore, we are studying if the p43/AIMP1 would clinically applicable. Development of Stem Cell Mobilizer Many clinicians are trying to treat diseases using stem cell. In some case, stem cells should be isolated from peripheral blood and manipulated in vitro to enrich stem cell. Big problem of in vitro manipulation of stem cell is genetic instability. If the stem cell mobilizer would be available, there could be a large amount of stem cell in peripheral blood. if so, we could minimize the genetic instability in vitro. Thus we are screening chemicals to induce stem cell mobilization. Development of Therapeutic Antibody Currently, we are developing therapeutic antibody, targeting rheumatoid arthritis(RA). Recently, we found that AIMP1 cytokine promoted osteoclastogenesis of macrophages and its level is increased in synovial fluid of RA patients. So we generated monoclonal antibody that neutralizes AIMP1 cytokine, and further developed chimeric antibody, which shows efficient attenuation of arthritis in collagen-induced arthritis mouse model. We developed fully humanized antibody, and are performing preclinical study. We are expecting that the atlizumab would be applicable to human body for the treatment of RA. |
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