교수진/연구실

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전임교수

교수정보의 상세 화면
박상규
이름
박상규
학력
박사
전공
약학전공(과)
정보
연구실 :
종합관 608호

연구실번호 :
3453

이메일 :
sgpark@ajou.ac.kr

연구관심분야 :
Stem Cells/Cancer/Drug Development

홈페이지 :
http://www.genefunctionlab.com
학력
졸업연도/학교/학위
2005.02 서울대학교 박사
경력 2007~2009 Assistant professor, Clinical Research Institute, Seoul National University Hospital 
2009.09~2014.09 Adjunctive professor, Graduate School of Convergence Science and Technology, Seoul National University
2009~2014.08 Associate professor, Department of Biomedical Science, College of Life Science, CHA University 
2014.09~present Associate professor, Dept.of Pharmacy, College of Pharmacy, AJOU University 
연구분야 Function Hunting of Med28 

Med28 was recently identified as a mediator of transcription complex, which involved in tumorigenesis including breast cancer, prostate cancer. However, its molecular mechanism is not understood. So we isolated binding candidates of med28, and are trying to unveil the molecular mechanism. Many candiates are shown to be associated with cancer progression such as DNA repair, chromosome segregation, suppressor of tumor suppressor, cell-cell signaling. 
 Thus we are studying about the novel regulatory mechanism in cancer onset and progression. 

p43/AIMP1 and Stem Cell 

p43/AIMP1 has been known as a multi-functional protein, which take part in immune cell activation, angiogenesis, blood glucose regulation, and wound healing as a cytokine. In addition, p43/AIMP1 regulates TGFb signaling and autoimmune disease in cytoplasm. Interestingly, whole body knock-out of p43/AIMP1 in mouse shows multiple phenotypes including defect of uterus development, petite, ataxia and so on...
 Thus we generated conditional knock-out mouse to remove p43/AIMP1 tissue specifically. 
 In addition, we are investigating whether the p43/AIMP1 could regulate stem cell mobilization from bone marrow, self-renewal, and differentiation of bone marrow-derived mesenchynal stem cell or hematopoietic stem cell. Furthermore, we are studying if the p43/AIMP1 would clinically applicable. 

Development of Stem Cell Mobilizer

Many clinicians are trying to treat diseases using stem cell. In some case, stem cells should be isolated from peripheral blood and manipulated in vitro to enrich stem cell. Big problem of in vitro manipulation of stem cell is genetic instability. If the stem cell mobilizer would be available, there could be a large amount of stem cell in peripheral blood. if so, we could minimize the genetic instability in vitro. 
 Thus we are screening chemicals to induce stem cell mobilization. 


Development of Therapeutic Antibody

Currently, we are developing therapeutic antibody, targeting rheumatoid arthritis(RA). Recently, we found that AIMP1 cytokine promoted osteoclastogenesis of macrophages and its level is increased in synovial fluid of RA patients. So we generated monoclonal antibody that neutralizes AIMP1 cytokine, and further developed chimeric antibody, which shows efficient attenuation of arthritis in collagen-induced arthritis mouse model. We developed fully humanized antibody, and are performing preclinical study. We are expecting that the atlizumab would be applicable to human body for the treatment of RA.
논문 및 연구활동
연구활동(주요논문)
  • [논문] Tauroursodeoxycholic Acid, a Bile Acid, Promotes Blood Vessel Repair by Recruiting Vasculogenic Progenitor Cells (STEM CELLS) - 2014.11
    박상규, 이준희, 홍신희, 이한나, 김철민, 권상모, 윤강준, 오배준, 김재현, 정석윤, Takayuki Asahara, 조진구, 김서윤
  • [논문] Isolation of adipose-derived stem cells by using a subfractionation culturing method (EXPERT OPINION ON BIOLOGICAL THERAPY) - 2014.11
    박상규, 이택기, 김왕균, 최준석, 송승용, 한준희, 성종혁, 김원석, 이현주, 조윤경, 황성주, 송순욱, 김지혜
  • [논문] Functional Regulation of Adipose-derived Stem Cells by PDGF-D (STEM CELLS) - 2014.10
    박상규, 성종혁, 송순욱, 김지혜, 김왕균
  • [논문] Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stability through its deubiquitinating activity (JOURNAL OF BIOLOGICAL CHEMISTRY) - 2013.11
    박상규, 조진구, 김철민, 강아영, 박경수, 안병용, 정성수, 임기환, 백광현, 성종혁, 이경원, 김민
  • [논문] ARS-interacting multi-functional protein 1 induces proliferation of human bone marrow-derived mesenchymal stem cells by accumulation of β-catenin via fibroblast growth factor receptor 2-mediated activation of Akt (STEM CELLS AND DEVELOPMENT) - 2013.10
    박상규, 손우성, 이수홍, 김철민, 차병현, 윤강준, 김서윤, 박민철
국제학술논문지
  • [논문] Tauroursodeoxycholic Acid, a Bile Acid, Promotes Blood Vessel Repair by Recruiting Vasculogenic Progenitor Cells (STEM CELLS) - 2014.11
    박상규, 이준희, 홍신희, 이한나, 김철민, 권상모, 윤강준, 오배준, 김재현, 정석윤, Takayuki Asahara, 조진구, 김서윤
  • [논문] Isolation of adipose-derived stem cells by using a subfractionation culturing method (EXPERT OPINION ON BIOLOGICAL THERAPY) - 2014.11
    박상규, 이택기, 김왕균, 최준석, 송승용, 한준희, 성종혁, 김원석, 이현주, 조윤경, 황성주, 송순욱, 김지혜
  • [논문] Functional Regulation of Adipose-derived Stem Cells by PDGF-D (STEM CELLS) - 2014.10
    박상규, 성종혁, 송순욱, 김지혜, 김왕균
  • [논문] Ultrasound-mediated gene and drug delivery using a microbubble-liposome particle system (THERANOSTICS) - 2014.09
    박상규, 윤태종, 권용수, 조희상, 허선희, 박경순, 이수홍, 황승일, 김영일, 제환준, 안국준, 조영석, 이학호, 이학종, 윤영일
  • [논문] The expression of aminoacyl-tRNA-synthetase-interacting multifunctional protein-1 (Aimp1) is regulated by estrogen in the mouse uterus (MOLECULAR AND CELLULAR ENDOCRINOLOGY) - 2014.08
    박상규, 정지혜, 박미리, 박미선, 임은진, Haengseok Song, 최은, 홍권호, 이동률, 고정재, 최영석, 김혜련
  • [논문] SMAD4 suppresses AURKA-induced Metastatic Phenotypes via Degradation of AURKA in a TGF-beta-independent manner (MOLECULAR CANCER RESEARCH) - 2014.07
    박상규, Lina Jia, 이훈석, Chun Fu Wu, Juthika Kundu, 김용남, 신영기, Ozgur Cem Erkin, 최종선, 채승완, 양호빈, 최윤라, 왕리휘
  • [논문] The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells (STEM CELLS AND DEVELOPMENT) - 2014.06
    박상규, 김지혜, 김왕균, 성영관, 곽미희, 송승용, 성종혁, 이택기, 이현주, 김대덕, 서현민, 송순욱, 최준석
  • [논문] The role of tauroursodeoxycholic acid on adipogenesis of human adipose-derived stem cells by modulation of ER stress (BIOMATERIALS) - 2014.03
    박상규, 차병현, 김진수, 이수홍, 김희천, 김병수, 한동근, 안종찬
  • [논문] Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor γ (PPARγ) stability through its deubiquitinating activity (JOURNAL OF BIOLOGICAL CHEMISTRY) - 2013.11
    박상규, 조진구, 김철민, 강아영, 박경수, 안병용, 정성수, 임기환, 백광현, 성종혁, 이경원, 김민
  • [논문] ARS-interacting multi-functional protein 1 induces proliferation of human bone marrow-derived mesenchymal stem cells by accumulation of β-catenin via fibroblast growth factor receptor 2-mediated activation of Akt (STEM CELLS AND DEVELOPMENT) - 2013.10
    박상규, 손우성, 이수홍, 김철민, 차병현, 윤강준, 김서윤, 박민철
  • [논문] Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2 (CELL DEATH & DISEASE) - 2013.04
    박상규, 성종혁, 김진경, 김지혜, 송승용
  • [논문] Convergent evolution of two different random RNAs for specific interaction with methionyl-tRNA synthetase (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS) - 2013.03
    박상규, 김규엽, 조영준, 강태희
특허 및 기타
  • [특허] 혈관신생을 위한 스텐트 코팅용 조성물 및 이의 용도 (출원) (10-2014-0168366) - 2014.11
    박상규, 홍신희, 조진구
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